Drug interactions
Eprosartan-hydrochlorothiazide + Ibuprofen
Severity: Moderate
Eprosartan-hydrochlorothiazide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the antihypertensive effect of the ARB and thiazide combination. Together with a diuretic and ARB it increases the risk of acute kidney injury and hyperkalemia, especially in older or dehydrated patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and lowers renal perfusion, opposing the diuretic and ARB and impairing kidney function.
What to do
Monitor blood pressure, creatinine and potassium, and maintain hydration. Prefer paracetamol or the lowest effective NSAID dose for a short course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Ibuprofen?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the antihypertensive effect of the ARB and thiazide combination. Together with a diuretic and ARB it increases the risk of acute kidney injury and hyperkalemia, especially in older or dehydrated patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, and maintain hydration. Prefer paracetamol or the lowest effective NSAID dose for a short course.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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