Drug interactions
Eprosartan-hydrochlorothiazide + Insulin degludec
Severity: Moderate
Eprosartan-hydrochlorothiazide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Glycemic control may deteriorate, particularly after starting the diuretic or increasing the dose. The ARB component may work in the opposite direction, so the net effect is variable.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazides reduce insulin secretion and sensitivity, partly via hypokalemia, opposing insulin action, while ARBs may slightly improve insulin sensitivity.
What to do
Monitor blood glucose when starting or adjusting the combination and adjust the insulin dose as needed. Correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Insulin degludec?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of insulin in patients with diabetes. Glycemic control may deteriorate, particularly after starting the diuretic or increasing the dose. The ARB component may work in the opposite direction, so the net effect is variable.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting the combination and adjust the insulin dose as needed. Correct hypokalemia.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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