Drug interactions
Eprosartan-hydrochlorothiazide + Lofexidine
Severity: Moderate
Eprosartan-hydrochlorothiazide and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate. Adding an ARB and a thiazide diuretic adds further blood pressure lowering, increasing the risk of hypotension, dizziness and syncope.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from central sympatholytic action plus vasodilation and volume depletion.
What to do
Monitor blood pressure and pulse before doses and during lofexidine therapy, and counsel patients about orthostatic symptoms. Reduce or hold the antihypertensive doses if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eprosartan-hydrochlorothiazide and Lofexidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Lofexidine?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a central alpha-2 agonist that lowers blood pressure and heart rate. Adding an ARB and a thiazide diuretic adds further blood pressure lowering, increasing the risk of hypotension, dizziness and syncope.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse before doses and during lofexidine therapy, and counsel patients about orthostatic symptoms. Reduce or hold the antihypertensive doses if hypotension or bradycardia develops.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
