Drug interactions
Eprosartan-hydrochlorothiazide + Naproxen
Severity: Moderate
Eprosartan-hydrochlorothiazide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can blunt the antihypertensive effect of the ARB and thiazide combination. Used together with a diuretic and ARB, it increases the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may raise potassium.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis leads to sodium and water retention and reduced glomerular perfusion, opposing the effects of ARB and diuretic.
What to do
Monitor blood pressure, serum creatinine and potassium after starting naproxen, and keep the patient well hydrated. Use the lowest effective dose for the shortest duration or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Naproxen?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can blunt the antihypertensive effect of the ARB and thiazide combination. Used together with a diuretic and ARB, it increases the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may raise potassium.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting naproxen, and keep the patient well hydrated. Use the lowest effective dose for the shortest duration or choose an alternative analgesic.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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