Drug interactions
Eprosartan-hydrochlorothiazide + Pioglitazone
Severity: Minor
Eprosartan-hydrochlorothiazide and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effect of pioglitazone. The impact is usually modest at low doses.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Pioglitazone belongs to Endocrine.
Why it happens
Thiazide-related reductions in insulin secretion and sensitivity oppose the insulin-sensitizing effect.
What to do
Monitor blood glucose and HbA1c after starting the combination. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Pioglitazone?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and reduce the effect of pioglitazone. The impact is usually modest at low doses.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting the combination. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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