Drug interactions
Eprosartan-hydrochlorothiazide + Propranolol
Severity: Minor
Eprosartan-hydrochlorothiazide and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the antihypertensive effect of eprosartan and hydrochlorothiazide, which may cause excessive hypotension or bradycardia. The combination is widely used and usually well tolerated.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects via beta-blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Propranolol?
MediHelp rates the interaction as minor. Eprosartan-hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol adds to the antihypertensive effect of eprosartan and hydrochlorothiazide, which may cause excessive hypotension or bradycardia. The combination is widely used and usually well tolerated.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses. Reduce doses if symptomatic hypotension or bradycardia appears.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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