Drug interactions
Eprosartan-hydrochlorothiazide + Quinine
Severity: Moderate
Eprosartan-hydrochlorothiazide and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may modestly reduce quinine clearance. More relevant is that thiazide-induced hypokalemia or hypomagnesemia can increase the risk of quinine-related QT prolongation.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Possible competition for renal tubular secretion, plus thiazide-induced electrolyte loss that adds to quinine's QT-prolonging effect.
What to do
Check and correct potassium and magnesium before and during quinine therapy. Obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Quinine?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide may modestly reduce quinine clearance. More relevant is that thiazide-induced hypokalemia or hypomagnesemia can increase the risk of quinine-related QT prolongation.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during quinine therapy. Obtain an ECG in patients with other QT risk factors.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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