Drug interactions
Eprosartan-hydrochlorothiazide + Salmeterol
Severity: Moderate
Eprosartan-hydrochlorothiazide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and long-acting beta-agonists can lower serum potassium. Together they may cause clinically significant hypokalemia and, rarely, ECG changes or arrhythmias, especially at high doses or with hypoxia.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Beta-2 stimulation shifts potassium into cells while the thiazide increases renal potassium excretion, producing additive hypokalemia.
What to do
Monitor serum potassium in patients with risk factors such as severe asthma or COPD, or those taking higher doses. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Salmeterol?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and long-acting beta-agonists can lower serum potassium. Together they may cause clinically significant hypokalemia and, rarely, ECG changes or arrhythmias, especially at high doses or with hypoxia.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with risk factors such as severe asthma or COPD, or those taking higher doses. Replace potassium as needed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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