Drug interactions
Eprosartan-hydrochlorothiazide + Spironolactone
Severity: Major
Eprosartan-hydrochlorothiazide and Spironolactone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan and spironolactone both promote potassium retention, while hydrochlorothiazide lowers potassium, so the net effect is hard to predict. Serious hyperkalemia can occur, particularly in renal impairment, diabetes, or heart failure.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade and aldosterone antagonism both reduce renal potassium excretion, partly offset by thiazide kaliuresis.
What to do
Monitor serum potassium and creatinine closely after initiation and with dose changes; avoid potassium supplements and salt substitutes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Spironolactone?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan and spironolactone both promote potassium retention, while hydrochlorothiazide lowers potassium, so the net effect is hard to predict. Serious hyperkalemia can occur, particularly in renal impairment, diabetes, or heart failure.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine closely after initiation and with dose changes; avoid potassium supplements and salt substitutes.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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