Drug interactions
Eprosartan-hydrochlorothiazide + Tolmetin
Severity: Moderate
Eprosartan-hydrochlorothiazide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin can reduce the blood pressure lowering effect of eprosartan and hydrochlorothiazide. The combination of an NSAID, an ARB and a diuretic increases the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion and sodium excretion, opposing the antihypertensive effect and adding to ARB-related renal hemodynamic stress.
What to do
Monitor blood pressure, serum creatinine and potassium within the first weeks of co-therapy. Avoid prolonged use and ensure adequate hydration, or switch to a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Tolmetin?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin can reduce the blood pressure lowering effect of eprosartan and hydrochlorothiazide. The combination of an NSAID, an ARB and a diuretic increases the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium within the first weeks of co-therapy. Avoid prolonged use and ensure adequate hydration, or switch to a non-NSAID analgesic.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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