Drug interactions
Eprosartan-hydrochlorothiazide + Tolvaptan
Severity: Moderate
Eprosartan-hydrochlorothiazide and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan causes aquaresis and, together with hydrochlorothiazide, can lead to excessive fluid loss, hypotension and electrolyte disturbance. Potassium may rise with the ARB, and serum sodium may correct too rapidly.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Additive pharmacodynamic diuresis from vasopressin V2 antagonism and thiazide action, with ARB-related potassium retention.
What to do
Monitor serum sodium, potassium, volume status and blood pressure closely, especially at initiation. Adjust or reduce the thiazide dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Tolvaptan?
MediHelp rates the interaction as moderate. Eprosartan-hydrochlorothiazide and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan causes aquaresis and, together with hydrochlorothiazide, can lead to excessive fluid loss, hypotension and electrolyte disturbance. Potassium may rise with the ARB, and serum sodium may correct too rapidly.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium, volume status and blood pressure closely, especially at initiation. Adjust or reduce the thiazide dose if volume depletion occurs.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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