Drug interactions
Eprosartan-hydrochlorothiazide + Triamterene
Severity: Major
Eprosartan-hydrochlorothiazide and Triamterene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan and triamterene both raise serum potassium, while hydrochlorothiazide opposes this, making the net effect unpredictable. Hyperkalemia and renal impairment are the key risks, especially in older or diabetic patients.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade reduces aldosterone-driven potassium excretion and triamterene blocks the epithelial sodium channel, partly offset by thiazide potassium loss.
What to do
Monitor serum potassium and renal function soon after starting and periodically thereafter; avoid potassium supplements and stop triamterene if hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Triamterene?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eprosartan and triamterene both raise serum potassium, while hydrochlorothiazide opposes this, making the net effect unpredictable. Hyperkalemia and renal impairment are the key risks, especially in older or diabetic patients.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function soon after starting and periodically thereafter; avoid potassium supplements and stop triamterene if hyperkalemia occurs.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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