Drug interactions
Eprosartan-hydrochlorothiazide + Valsartan
Severity: Major
Eprosartan-hydrochlorothiazide and Valsartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers gives no meaningful added benefit and increases hypotension, hyperkalemia and renal dysfunction. Dual renin-angiotensin blockade is generally discouraged.
What this interaction means in plain words
Eprosartan-hydrochlorothiazide and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eprosartan-hydrochlorothiazide belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II receptor blockade causes additive reduction of aldosterone effect and glomerular filtration pressure.
What to do
Avoid combining two ARBs and use a single agent at an optimized dose. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Eprosartan-hydrochlorothiazide with Valsartan?
MediHelp rates the interaction as major. Eprosartan-hydrochlorothiazide and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers gives no meaningful added benefit and increases hypotension, hyperkalemia and renal dysfunction. Dual renin-angiotensin blockade is generally discouraged.
How serious is the interaction between Eprosartan-hydrochlorothiazide and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs and use a single agent at an optimized dose. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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