Drug interactions
Erdafitinib + Erythromycin
Severity: Moderate
Erdafitinib and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may modestly raise levels of P-gp substrates. Erythromycin is a P-gp substrate, though not a narrow-index one, so the effect is likely modest. Erythromycin also inhibits CYP3A4, which contributes to erdafitinib metabolism, and may raise erdafitinib levels.
What this interaction means in plain words
Erdafitinib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Erdafitinib inhibits P-gp efflux of erythromycin, and erythromycin inhibits CYP3A4 metabolism of erdafitinib.
What to do
Monitor for erdafitinib adverse effects such as hyperphosphatemia, ocular and skin toxicity, and for erythromycin GI effects or QT prolongation. Consider an alternative antibiotic if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Erythromycin?
MediHelp rates the interaction as moderate. Erdafitinib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may modestly raise levels of P-gp substrates. Erythromycin is a P-gp substrate, though not a narrow-index one, so the effect is likely modest. Erythromycin also inhibits CYP3A4, which contributes to erdafitinib metabolism, and may raise erdafitinib levels.
How serious is the interaction between Erdafitinib and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib adverse effects such as hyperphosphatemia, ocular and skin toxicity, and for erythromycin GI effects or QT prolongation. Consider an alternative antibiotic if toxicity develops.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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