Drug interactions
Erdafitinib + Flurbiprofen
Severity: Minor
Erdafitinib and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is partly metabolized by CYP2C9, and strong CYP2C9 inhibitors can raise its exposure. Flurbiprofen is a CYP2C9 substrate rather than a strong inhibitor, so a meaningful increase is unlikely.
What this interaction means in plain words
Erdafitinib and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Flurbiprofen is a CYP2C9 substrate and may compete weakly, but does not strongly inhibit erdafitinib metabolism.
What to do
No erdafitinib dose adjustment is needed. Continue routine monitoring for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Flurbiprofen?
MediHelp rates the interaction as minor. Erdafitinib and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is partly metabolized by CYP2C9, and strong CYP2C9 inhibitors can raise its exposure. Flurbiprofen is a CYP2C9 substrate rather than a strong inhibitor, so a meaningful increase is unlikely.
How serious is the interaction between Erdafitinib and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No erdafitinib dose adjustment is needed. Continue routine monitoring for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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