Drug interactions
Erdafitinib + Fluvastatin
Severity: Moderate
Erdafitinib and Fluvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared partly by CYP2C9, and fluvastatin is a CYP2C9 substrate with inhibitory activity. Fluvastatin is a weak-to-moderate inhibitor, not a strong one, so the rise in erdafitinib exposure is likely modest but could increase hyperphosphatemia, ocular and skin toxicity.
What this interaction means in plain words
Erdafitinib and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Fluvastatin belongs to Cardiovascular.
Why it happens
Fluvastatin may inhibit CYP2C9-mediated metabolism of erdafitinib, increasing erdafitinib exposure.
What to do
Monitor for erdafitinib adverse effects, including serum phosphate and ocular symptoms, and reduce the erdafitinib dose if toxicity occurs. Consider a statin that does not inhibit CYP2C9 if the combination is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Fluvastatin?
MediHelp rates the interaction as moderate. Erdafitinib and Fluvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib is cleared partly by CYP2C9, and fluvastatin is a CYP2C9 substrate with inhibitory activity. Fluvastatin is a weak-to-moderate inhibitor, not a strong one, so the rise in erdafitinib exposure is likely modest but could increase hyperphosphatemia, ocular and skin toxicity.
How serious is the interaction between Erdafitinib and Fluvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib adverse effects, including serum phosphate and ocular symptoms, and reduce the erdafitinib dose if toxicity occurs. Consider a statin that does not inhibit CYP2C9 if the combination is problematic.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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