Drug interactions
Erdafitinib + Glyburide-metformin
Severity: Minor
Erdafitinib and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is an OCT2 substrate and metformin may compete for renal secretion via OCT2, potentially modestly increasing erdafitinib exposure. This could increase erdafitinib adverse effects such as hyperphosphatemia, stomatitis and ocular toxicity.
What this interaction means in plain words
Erdafitinib and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Glyburide-metformin belongs to Endocrine.
Why it happens
Metformin may inhibit OCT2-mediated renal tubular secretion of erdafitinib, reducing its renal clearance.
What to do
Monitor for erdafitinib adverse effects, including serum phosphate and ocular symptoms. Reduce the erdafitinib dose per labeling if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Glyburide-metformin?
MediHelp rates the interaction as minor. Erdafitinib and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is an OCT2 substrate and metformin may compete for renal secretion via OCT2, potentially modestly increasing erdafitinib exposure. This could increase erdafitinib adverse effects such as hyperphosphatemia, stomatitis and ocular toxicity.
How serious is the interaction between Erdafitinib and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib adverse effects, including serum phosphate and ocular symptoms. Reduce the erdafitinib dose per labeling if toxicity develops.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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