Drug interactions
Erdafitinib + Ibuprofen
Severity: Minor
Erdafitinib and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is partly metabolized by CYP2C9, and strong CYP2C9 inhibitors can raise its exposure and toxicity. Ibuprofen is a CYP2C9 substrate and not a strong inhibitor, so a clinically meaningful effect is unlikely.
What this interaction means in plain words
Erdafitinib and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Ibuprofen belongs to Musculoskeletal.
Why it happens
Ibuprofen is a CYP2C9 substrate with weak competitive effect on erdafitinib metabolism, not strong inhibition.
What to do
No dose change of erdafitinib is needed. Monitor for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Ibuprofen?
MediHelp rates the interaction as minor. Erdafitinib and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erdafitinib is partly metabolized by CYP2C9, and strong CYP2C9 inhibitors can raise its exposure and toxicity. Ibuprofen is a CYP2C9 substrate and not a strong inhibitor, so a clinically meaningful effect is unlikely.
How serious is the interaction between Erdafitinib and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change of erdafitinib is needed. Monitor for erdafitinib adverse effects such as hyperphosphatemia and ocular toxicity as usual.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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