Drug interactions
Erdafitinib + Ledipasvir-sofosbuvir
Severity: Moderate
Erdafitinib and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib can inhibit intestinal P-glycoprotein, which may raise exposure to ledipasvir and sofosbuvir, both P-gp substrates. The expected rise is modest and these agents have a wide safety margin, so the clinical consequence is usually limited.
What this interaction means in plain words
Erdafitinib and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
Erdafitinib inhibits P-gp efflux, potentially increasing absorption and plasma levels of P-gp substrates.
What to do
Coadministration is acceptable with monitoring for adverse effects of the antiviral combination. If a separation strategy is chosen, give the antiviral at least 6 hours before or after erdafitinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Erdafitinib and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib can inhibit intestinal P-glycoprotein, which may raise exposure to ledipasvir and sofosbuvir, both P-gp substrates. The expected rise is modest and these agents have a wide safety margin, so the clinical consequence is usually limited.
How serious is the interaction between Erdafitinib and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Coadministration is acceptable with monitoring for adverse effects of the antiviral combination. If a separation strategy is chosen, give the antiviral at least 6 hours before or after erdafitinib.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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