Drug interactions
Erdafitinib + Morphine
Severity: Moderate
Erdafitinib and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and could raise exposure to P-gp substrates such as morphine. The clinical effect on morphine is probably modest but may cause increased opioid effects.
What this interaction means in plain words
Erdafitinib and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Morphine belongs to Musculoskeletal.
Why it happens
Inhibition of P-glycoprotein efflux, increasing absorption and CNS penetration of morphine.
What to do
Monitor for increased sedation and respiratory depression, and reduce the morphine dose if these occur. Where feasible, separate dosing by at least 6 hours as labeling suggests for P-gp substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Morphine?
MediHelp rates the interaction as moderate. Erdafitinib and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and could raise exposure to P-gp substrates such as morphine. The clinical effect on morphine is probably modest but may cause increased opioid effects.
How serious is the interaction between Erdafitinib and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and respiratory depression, and reduce the morphine dose if these occur. Where feasible, separate dosing by at least 6 hours as labeling suggests for P-gp substrates.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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