Drug interactions
Erdafitinib + Pyrimethamine
Severity: Minor
Erdafitinib and Pyrimethamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyrimethamine is not an established strong CYP2C9 inhibitor, so the predicted rise in erdafitinib exposure is uncertain. Erdafitinib toxicity includes hyperphosphatemia and ocular and skin effects.
What this interaction means in plain words
Erdafitinib and Pyrimethamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erdafitinib belongs to Oncology; Pyrimethamine belongs to Anti Parasitic.
Why it happens
Possible weak CYP2C9 inhibition; the mechanism is not firmly established.
What to do
No empiric dose change is needed. Monitor for erdafitinib adverse reactions and serum phosphate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pyrimethamine
- Deferiprone + Pyrimethamine Major
- Eliglustat + Pyrimethamine Major
- Acalabrutinib + Pyrimethamine Moderate
- Brexpiprazole + Pyrimethamine Moderate
- Dapsone + Pyrimethamine Moderate
- Folic acid + Pyrimethamine Moderate
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Pyrimethamine?
MediHelp rates the interaction as minor. Erdafitinib and Pyrimethamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyrimethamine is not an established strong CYP2C9 inhibitor, so the predicted rise in erdafitinib exposure is uncertain. Erdafitinib toxicity includes hyperphosphatemia and ocular and skin effects.
How serious is the interaction between Erdafitinib and Pyrimethamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for erdafitinib adverse reactions and serum phosphate.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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