Drug interactions
Erdafitinib + Quinine
Severity: Moderate
Erdafitinib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is metabolized partly by CYP3A4 and may alter exposure to sensitive CYP3A4 substrates. Quinine is a CYP3A4 substrate, though its effect on erdafitinib is not well characterized, so the clinical impact is uncertain.
What this interaction means in plain words
Erdafitinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Erdafitinib may modulate CYP3A4 activity and affect quinine metabolism; the effect is not well established.
What to do
Monitor for quinine toxicity such as cinchonism and QT prolongation, or loss of efficacy. Obtain an ECG if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Quinine?
MediHelp rates the interaction as moderate. Erdafitinib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib is metabolized partly by CYP3A4 and may alter exposure to sensitive CYP3A4 substrates. Quinine is a CYP3A4 substrate, though its effect on erdafitinib is not well characterized, so the clinical impact is uncertain.
How serious is the interaction between Erdafitinib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as cinchonism and QT prolongation, or loss of efficacy. Obtain an ECG if used together.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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