Drug interactions
Erdafitinib + Sorafenib
Severity: Moderate
Erdafitinib and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib is cleared mainly by CYP2C9 and CYP3A4. Sorafenib inhibits CYP2C9 in vitro, which could raise erdafitinib exposure and increase its toxicities, such as hyperphosphatemia, ocular and skin effects.
What this interaction means in plain words
Erdafitinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Possible inhibition of CYP2C9-mediated erdafitinib metabolism by sorafenib.
What to do
Monitor closely for erdafitinib adverse reactions, including serum phosphate and eye symptoms. Reduce the erdafitinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erdafitinib and Sorafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sorafenib
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Sorafenib?
MediHelp rates the interaction as moderate. Erdafitinib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib is cleared mainly by CYP2C9 and CYP3A4. Sorafenib inhibits CYP2C9 in vitro, which could raise erdafitinib exposure and increase its toxicities, such as hyperphosphatemia, ocular and skin effects.
How serious is the interaction between Erdafitinib and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for erdafitinib adverse reactions, including serum phosphate and eye symptoms. Reduce the erdafitinib dose if toxicity occurs.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
