Drug interactions
Erdafitinib + Vincristine
Severity: Major
Erdafitinib and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein, and vincristine is a substrate with a narrow therapeutic index. Increased vincristine exposure could intensify neurotoxicity and gastrointestinal toxicity.
What this interaction means in plain words
Erdafitinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erdafitinib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Erdafitinib inhibits P-glycoprotein efflux, increasing vincristine absorption and reducing its elimination.
What to do
Avoid concurrent use where possible. If unavoidable, separate erdafitinib from vincristine by at least 6 hours as labeled and monitor for neurotoxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Vincristine?
MediHelp rates the interaction as major. Erdafitinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib inhibits P-glycoprotein, and vincristine is a substrate with a narrow therapeutic index. Increased vincristine exposure could intensify neurotoxicity and gastrointestinal toxicity.
How serious is the interaction between Erdafitinib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If unavoidable, separate erdafitinib from vincristine by at least 6 hours as labeled and monitor for neurotoxicity.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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