Drug interactions
Ergoloid mesylates + Mifepristone
Severity: Major
Ergoloid mesylates and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise ergoloid mesylate exposure, with a possible risk of ergot toxicity. Ergoloid mesylates have weaker vasoconstrictor activity than other ergots, so the risk is likely less than with ergotamine.
What this interaction means in plain words
Ergoloid mesylates and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mifepristone inhibits CYP3A4-mediated metabolism of ergoloid mesylates.
What to do
Avoid the combination, and hold ergoloid mesylates during mifepristone therapy. Watch for nausea, vasospasm and ischemic symptoms if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Mifepristone?
MediHelp rates the interaction as major. Ergoloid mesylates and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and may raise ergoloid mesylate exposure, with a possible risk of ergot toxicity. Ergoloid mesylates have weaker vasoconstrictor activity than other ergots, so the risk is likely less than with ergotamine.
How serious is the interaction between Ergoloid mesylates and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and hold ergoloid mesylates during mifepristone therapy. Watch for nausea, vasospasm and ischemic symptoms if it cannot be avoided.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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