Drug interactions
Ergoloid mesylates + Ziprasidone
Severity: Moderate
Ergoloid mesylates and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergoloid mesylates have dopaminergic and serotonergic activity that may interact with ziprasidone's receptor blockade. Case-level concern exists for serotonin toxicity or neuroleptic malignant syndrome, though evidence is sparse.
What this interaction means in plain words
Ergoloid mesylates and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Overlapping dopaminergic and serotonergic receptor effects; mechanism not firmly established.
What to do
Monitor for fever, rigidity, agitation, tremor and autonomic instability when starting or adjusting either drug. Discontinue and treat if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Ziprasidone?
MediHelp rates the interaction as moderate. Ergoloid mesylates and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergoloid mesylates have dopaminergic and serotonergic activity that may interact with ziprasidone's receptor blockade. Case-level concern exists for serotonin toxicity or neuroleptic malignant syndrome, though evidence is sparse.
How serious is the interaction between Ergoloid mesylates and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fever, rigidity, agitation, tremor and autonomic instability when starting or adjusting either drug. Discontinue and treat if toxicity occurs.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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