Drug interactions
Eribulin + Fingolimod
Severity: Major
Eribulin and Fingolimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and fingolimod causes bradycardia and may also affect QT. The combination increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Eribulin and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Fingolimod belongs to Central Nervous System.
Why it happens
Additive QT prolongation aggravated by bradycardia.
What to do
Obtain a baseline ECG and correct electrolytes before eribulin. Monitor ECG and heart rate periodically, and seek cardiology advice if QTc is prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Fingolimod?
MediHelp rates the interaction as major. Eribulin and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval, and fingolimod causes bradycardia and may also affect QT. The combination increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Eribulin and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before eribulin. Monitor ECG and heart rate periodically, and seek cardiology advice if QTc is prolonged.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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