Drug interactions
Eribulin + Foscarnet
Severity: Major
Eribulin and Foscarnet: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and foscarnet also causes electrolyte disturbances such as hypocalcemia, hypomagnesemia and hypokalemia that further raise arrhythmia risk. Combined use may increase the chance of torsades de pointes.
What this interaction means in plain words
Eribulin and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Foscarnet belongs to Anti Virals.
Why it happens
Additive QT prolongation, worsened by foscarnet-induced electrolyte disturbances.
What to do
Avoid the combination if possible; otherwise obtain a baseline ECG, correct potassium, magnesium and calcium before and during treatment, and monitor the ECG and electrolytes regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Foscarnet?
MediHelp rates the interaction as major. Eribulin and Foscarnet can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and foscarnet also causes electrolyte disturbances such as hypocalcemia, hypomagnesemia and hypokalemia that further raise arrhythmia risk. Combined use may increase the chance of torsades de pointes.
How serious is the interaction between Eribulin and Foscarnet?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise obtain a baseline ECG, correct potassium, magnesium and calcium before and during treatment, and monitor the ECG and electrolytes regularly.
What other medicines interact with Foscarnet?
MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.
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