Drug interactions
Eribulin + Givinostat
Severity: Major
Eribulin and Givinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so combined use raises the risk of torsades de pointes. Givinostat labeling advises ECG surveillance with QT-prolonging drugs.
What this interaction means in plain words
Eribulin and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Givinostat belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation.
What to do
Obtain ECGs at initiation and periodically, and monitor electrolytes. Withhold givinostat if QTc exceeds 500 ms or rises by more than 60 ms from baseline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Eribulin with Givinostat?
MediHelp rates the interaction as major. Eribulin and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so combined use raises the risk of torsades de pointes. Givinostat labeling advises ECG surveillance with QT-prolonging drugs.
How serious is the interaction between Eribulin and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and periodically, and monitor electrolytes. Withhold givinostat if QTc exceeds 500 ms or rises by more than 60 ms from baseline.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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