Drug interactions
Eribulin + Imipramine
Severity: Moderate
Eribulin and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and imipramine also affects cardiac repolarization. The combination may increase the risk of ventricular arrhythmias, particularly with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Eribulin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Imipramine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Perform ECG monitoring and correct potassium and magnesium abnormalities before and during treatment. Consider an alternative antidepressant if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Imipramine?
MediHelp rates the interaction as moderate. Eribulin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval, and imipramine also affects cardiac repolarization. The combination may increase the risk of ventricular arrhythmias, particularly with electrolyte abnormalities or heart disease.
How serious is the interaction between Eribulin and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring and correct potassium and magnesium abnormalities before and during treatment. Consider an alternative antidepressant if the QTc becomes significantly prolonged.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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