Drug interactions
Eribulin + Ivosidenib
Severity: Major
Eribulin and Ivosidenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval in a dose-related way, and eribulin has a similar effect. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Eribulin and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Ivosidenib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Avoid the pair if possible. If it is necessary, monitor ECG and electrolytes regularly and follow ivosidenib labeling for dose interruption or reduction if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Eribulin with Ivosidenib?
MediHelp rates the interaction as major. Eribulin and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib prolongs the QT interval in a dose-related way, and eribulin has a similar effect. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Eribulin and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the pair if possible. If it is necessary, monitor ECG and electrolytes regularly and follow ivosidenib labeling for dose interruption or reduction if QTc rises significantly.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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