Drug interactions
Eribulin + Lefamulin
Severity: Major
Eribulin and Lefamulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Together they may produce additive effects and raise the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Eribulin and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Choose a non-QT-prolonging antibiotic if feasible. If lefamulin is required, obtain ECG monitoring and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Eribulin with Lefamulin?
MediHelp rates the interaction as major. Eribulin and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval. Together they may produce additive effects and raise the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Eribulin and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-QT-prolonging antibiotic if feasible. If lefamulin is required, obtain ECG monitoring and correct hypokalemia and hypomagnesemia.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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