Drug interactions
Eribulin + Methadone
Severity: Major
Eribulin and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval, and methadone also prolongs QT, so combined use may increase the risk of torsades de pointes. The risk is higher with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Eribulin and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT interval prolongation.
What to do
Obtain an ECG at baseline and periodically during treatment, and correct potassium and magnesium. Consider an alternative analgesic if QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Methadone?
MediHelp rates the interaction as major. Eribulin and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eribulin can prolong the QT interval, and methadone also prolongs QT, so combined use may increase the risk of torsades de pointes. The risk is higher with electrolyte abnormalities or heart disease.
How serious is the interaction between Eribulin and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and periodically during treatment, and correct potassium and magnesium. Consider an alternative analgesic if QTc becomes significantly prolonged.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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