Drug interactions
Eribulin + Nilotinib
Severity: Major
Eribulin and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and sudden death, and eribulin can also lengthen the QT interval. Together they may enhance the risk of serious ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Eribulin and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Prefer an alternative to one of the agents; if concurrent use is necessary, perform baseline and periodic ECG monitoring and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Eribulin with Nilotinib?
MediHelp rates the interaction as major. Eribulin and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib carries a boxed warning for QT prolongation and sudden death, and eribulin can also lengthen the QT interval. Together they may enhance the risk of serious ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Eribulin and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to one of the agents; if concurrent use is necessary, perform baseline and periodic ECG monitoring and keep potassium and magnesium within normal range.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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