Drug interactions
Eribulin + Palifermin
Severity: Moderate
Eribulin and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth and given close to cytotoxic chemotherapy has been linked with worse and longer oral mucositis. Eribulin is a cytotoxic agent, so the same timing concern is expected.
What this interaction means in plain words
Eribulin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-driven epithelial proliferation may increase susceptibility of mucosal cells to cytotoxic damage.
What to do
Give palifermin outside the window from 24 hours before to 24 hours after eribulin. Monitor oral mucosa for severity of mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Palifermin
Frequently asked questions
Can I take Eribulin with Palifermin?
MediHelp rates the interaction as moderate. Eribulin and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell growth and given close to cytotoxic chemotherapy has been linked with worse and longer oral mucositis. Eribulin is a cytotoxic agent, so the same timing concern is expected.
How serious is the interaction between Eribulin and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give palifermin outside the window from 24 hours before to 24 hours after eribulin. Monitor oral mucosa for severity of mucositis.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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