Drug interactions
Eribulin + Pazopanib
Severity: Major
Eribulin and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, so concurrent use may increase the likelihood of clinically significant arrhythmias such as torsades de pointes. The risk is higher in patients with electrolyte disturbances, heart disease or bradycardia.
What this interaction means in plain words
Eribulin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid combining when alternatives exist; otherwise monitor ECG at baseline and periodically and correct potassium and magnesium deficits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Eribulin with Pazopanib?
MediHelp rates the interaction as major. Eribulin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents have been associated with QT prolongation, so concurrent use may increase the likelihood of clinically significant arrhythmias such as torsades de pointes. The risk is higher in patients with electrolyte disturbances, heart disease or bradycardia.
How serious is the interaction between Eribulin and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when alternatives exist; otherwise monitor ECG at baseline and periodically and correct potassium and magnesium deficits.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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