Drug interactions
Eribulin + Salmeterol
Severity: Moderate
Eribulin and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin can prolong the QT interval and salmeterol, particularly at higher exposures, may also affect repolarisation and lower potassium. Together they may raise the risk of ventricular arrhythmias, especially with electrolyte disturbances.
What this interaction means in plain words
Eribulin and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia potentially adding to the risk.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat ECG and electrolytes periodically while both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Eribulin
Frequently asked questions
Can I take Eribulin with Salmeterol?
MediHelp rates the interaction as moderate. Eribulin and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eribulin can prolong the QT interval and salmeterol, particularly at higher exposures, may also affect repolarisation and lower potassium. Together they may raise the risk of ventricular arrhythmias, especially with electrolyte disturbances.
How serious is the interaction between Eribulin and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat ECG and electrolytes periodically while both are used.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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