Drug interactions
Eribulin + Selpercatinib
Severity: Moderate
Eribulin and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so together they may raise the risk of torsades de pointes. Selpercatinib labeling advises caution with other QT-prolonging drugs.
What this interaction means in plain words
Eribulin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eribulin belongs to Oncology; Selpercatinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes at baseline and periodically, correcting potassium, magnesium and calcium. Interrupt or reduce selpercatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Selpercatinib
Frequently asked questions
Can I take Eribulin with Selpercatinib?
MediHelp rates the interaction as moderate. Eribulin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so together they may raise the risk of torsades de pointes. Selpercatinib labeling advises caution with other QT-prolonging drugs.
How serious is the interaction between Eribulin and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, correcting potassium, magnesium and calcium. Interrupt or reduce selpercatinib if QTc becomes markedly prolonged.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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