Drug interactions
Eribulin + Sunitinib
Severity: Major
Eribulin and Sunitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval and eribulin has similar effects, so the combination may enhance the risk of torsades de pointes. Risk is higher with electrolyte abnormalities, bradycardia or structural heart disease.
What this interaction means in plain words
Eribulin and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eribulin belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Use an alternative to one agent if possible; if both are required, monitor ECG periodically and keep potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Eribulin with Sunitinib?
MediHelp rates the interaction as major. Eribulin and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sunitinib can prolong the QT interval and eribulin has similar effects, so the combination may enhance the risk of torsades de pointes. Risk is higher with electrolyte abnormalities, bradycardia or structural heart disease.
How serious is the interaction between Eribulin and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to one agent if possible; if both are required, monitor ECG periodically and keep potassium and magnesium in the normal range.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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