Drug interactions
Erlotinib + Istradefylline
Severity: Minor
Erlotinib and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg daily can raise exposure to CYP3A4 substrates, which may increase erlotinib levels. The effect is not seen at 20 mg daily.
What this interaction means in plain words
Erlotinib and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erlotinib belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent CYP3A4 inhibition by istradefylline.
What to do
Monitor for erlotinib adverse effects when istradefylline 40 mg is used. Reduce erlotinib dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Erlotinib and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Erlotinib with Istradefylline?
MediHelp rates the interaction as minor. Erlotinib and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg daily can raise exposure to CYP3A4 substrates, which may increase erlotinib levels. The effect is not seen at 20 mg daily.
How serious is the interaction between Erlotinib and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib adverse effects when istradefylline 40 mg is used. Reduce erlotinib dose if toxicity develops.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
