Drug interactions
Erlotinib + Miconazole
Severity: Moderate
Erlotinib and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erlotinib is cleared mainly by CYP3A4, and strong inhibitors increase its exposure. Miconazole may raise erlotinib levels, but with vaginal use the effect is likely limited. Higher levels may worsen rash, diarrhea and rarely interstitial lung disease.
What this interaction means in plain words
Erlotinib and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, reducing erlotinib metabolism.
What to do
Monitor for increased rash and diarrhea and report new respiratory symptoms. Reduce the erlotinib dose if severe reactions occur and consider a non-azole antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Miconazole?
MediHelp rates the interaction as moderate. Erlotinib and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erlotinib is cleared mainly by CYP3A4, and strong inhibitors increase its exposure. Miconazole may raise erlotinib levels, but with vaginal use the effect is likely limited. Higher levels may worsen rash, diarrhea and rarely interstitial lung disease.
How serious is the interaction between Erlotinib and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased rash and diarrhea and report new respiratory symptoms. Reduce the erlotinib dose if severe reactions occur and consider a non-azole antifungal.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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