Drug interactions
Erlotinib + Nifedipine
Severity: Minor
Erlotinib and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erlotinib is metabolized by CYP3A4, but nifedipine is at most a weak inhibitor, so any increase in erlotinib exposure is expected to be small. A clinically significant effect has not been established.
What this interaction means in plain words
Erlotinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erlotinib belongs to Oncology; Nifedipine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by nifedipine reducing erlotinib metabolism.
What to do
No routine adjustment is needed; monitor for erlotinib adverse effects such as rash and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Nifedipine?
MediHelp rates the interaction as minor. Erlotinib and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erlotinib is metabolized by CYP3A4, but nifedipine is at most a weak inhibitor, so any increase in erlotinib exposure is expected to be small. A clinically significant effect has not been established.
How serious is the interaction between Erlotinib and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for erlotinib adverse effects such as rash and diarrhea.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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