Drug interactions
Erlotinib + Nilotinib
Severity: Moderate
Erlotinib and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise erlotinib exposure, which is mainly cleared by CYP3A4. This may increase erlotinib adverse effects such as rash, diarrhea and rarely interstitial lung disease.
What this interaction means in plain words
Erlotinib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erlotinib belongs to Oncology; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated erlotinib metabolism by nilotinib.
What to do
Monitor for erlotinib toxicity such as severe rash and diarrhea, and reduce the erlotinib dose if these occur. Also monitor the ECG because nilotinib prolongs QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Nilotinib?
MediHelp rates the interaction as moderate. Erlotinib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise erlotinib exposure, which is mainly cleared by CYP3A4. This may increase erlotinib adverse effects such as rash, diarrhea and rarely interstitial lung disease.
How serious is the interaction between Erlotinib and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity such as severe rash and diarrhea, and reduce the erlotinib dose if these occur. Also monitor the ECG because nilotinib prolongs QTc.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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