Drug interactions
Erlotinib + Nizatidine
Severity: Major
Erlotinib and Nizatidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erlotinib solubility falls as pH rises, so acid-reducing agents lower its absorption. This may reduce erlotinib exposure and antitumor efficacy.
What this interaction means in plain words
Erlotinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erlotinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Decreased pH-dependent dissolution of erlotinib caused by gastric acid suppression.
What to do
If an H2 blocker is needed, take erlotinib at least 2 hours before or 10 hours after the H2 blocker. Avoid the combination when practical.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
- Nizatidine + Rilpivirine Major
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Erlotinib with Nizatidine?
MediHelp rates the interaction as major. Erlotinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erlotinib solubility falls as pH rises, so acid-reducing agents lower its absorption. This may reduce erlotinib exposure and antitumor efficacy.
How serious is the interaction between Erlotinib and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an H2 blocker is needed, take erlotinib at least 2 hours before or 10 hours after the H2 blocker. Avoid the combination when practical.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Itraconazole. The full list is on the Nizatidine page.
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