Drug interactions
Dasatinib + Nizatidine
Severity: Major
Dasatinib and Nizatidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
What this interaction means in plain words
Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Reduced pH-dependent dissolution and absorption of dasatinib due to gastric acid suppression.
What to do
Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
- Nizatidine + Rilpivirine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Nizatidine?
MediHelp rates the interaction as major. Dasatinib and Nizatidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on an acidic gastric environment, and H2 blockers raise gastric pH. Exposure to dasatinib may fall, risking reduced antileukemic efficacy.
How serious is the interaction between Dasatinib and Nizatidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use short-acting antacids instead, given about 2 hours before or after dasatinib.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Erlotinib, Itraconazole. The full list is on the Nizatidine page.
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