Drug interactions
Ertapenem + Probenecid
Severity: Minor
Ertapenem and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal clearance of ertapenem, raising its levels and prolonging its half-life. The effect is of limited importance and is not recommended as a deliberate strategy.
What this interaction means in plain words
Ertapenem and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ertapenem belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular secretion of ertapenem via organic anion transporters.
What to do
No routine adjustment is needed; avoid using probenecid solely to extend ertapenem exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Ertapenem
- Ertapenem + Valproic acid Contraindicated
- Ertapenem + Typhoid vaccine live Major
- Cholera vaccine + Ertapenem Moderate
- Ertapenem + Microbiota Moderate
- Ertapenem + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Bcg vaccine live + Ertapenem Minor
Frequently asked questions
Can I take Ertapenem with Probenecid?
MediHelp rates the interaction as minor. Ertapenem and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid reduces renal clearance of ertapenem, raising its levels and prolonging its half-life. The effect is of limited importance and is not recommended as a deliberate strategy.
How serious is the interaction between Ertapenem and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; avoid using probenecid solely to extend ertapenem exposure.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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