Drug interactions
Erythromycin + Istradefylline
Severity: Moderate
Erythromycin and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses can raise exposure to CYP3A4 and P-glycoprotein substrates, which include erythromycin. Increased erythromycin levels may enhance its adverse effects, including gastrointestinal upset and QT prolongation.
What this interaction means in plain words
Erythromycin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline, at 40 mg/day, inhibits CYP3A4 and P-glycoprotein, reducing erythromycin clearance and efflux.
What to do
Keep the istradefylline dose at 20 mg/day where possible and monitor for erythromycin adverse effects. Check ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Erythromycin with Istradefylline?
MediHelp rates the interaction as moderate. Erythromycin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses can raise exposure to CYP3A4 and P-glycoprotein substrates, which include erythromycin. Increased erythromycin levels may enhance its adverse effects, including gastrointestinal upset and QT prolongation.
How serious is the interaction between Erythromycin and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the istradefylline dose at 20 mg/day where possible and monitor for erythromycin adverse effects. Check ECG in patients with QT risk factors.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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