Drug interactions
Erythromycin + Lorlatinib
Severity: Moderate
Erythromycin and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower erythromycin concentrations, which could reduce antibacterial effect. The reverse interaction is also relevant because erythromycin, a CYP3A4 inhibitor, may raise lorlatinib levels.
What this interaction means in plain words
Erythromycin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing erythromycin metabolism; erythromycin inhibits CYP3A4 and may raise lorlatinib exposure.
What to do
Monitor for antibacterial treatment failure and for lorlatinib adverse effects such as CNS effects, lipid elevation and PR prolongation. Consider an alternative antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Erythromycin with Lorlatinib?
MediHelp rates the interaction as moderate. Erythromycin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower erythromycin concentrations, which could reduce antibacterial effect. The reverse interaction is also relevant because erythromycin, a CYP3A4 inhibitor, may raise lorlatinib levels.
How serious is the interaction between Erythromycin and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antibacterial treatment failure and for lorlatinib adverse effects such as CNS effects, lipid elevation and PR prolongation. Consider an alternative antibiotic if feasible.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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