Drug interactions
Erythromycin + Lumateperone
Severity: Moderate
Erythromycin and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin increases lumateperone exposure, which may worsen sedation, orthostatic hypotension and other dose-related adverse effects.
What this interaction means in plain words
Erythromycin and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Lumateperone belongs to Central Nervous System.
Why it happens
Moderate CYP3A4 inhibition by erythromycin decreases the metabolism of lumateperone.
What to do
Reduce lumateperone to 21 mg daily while erythromycin is co-administered. Monitor for sedation and blood pressure changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Erythromycin with Lumateperone?
MediHelp rates the interaction as moderate. Erythromycin and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin increases lumateperone exposure, which may worsen sedation, orthostatic hypotension and other dose-related adverse effects.
How serious is the interaction between Erythromycin and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 21 mg daily while erythromycin is co-administered. Monitor for sedation and blood pressure changes.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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