Drug interactions
Erythromycin + Oxybutynin
Severity: Minor
Erythromycin and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase oxybutynin exposure, particularly of the oral immediate-release form. This may heighten anticholinergic effects such as dry mouth, constipation, drowsiness and confusion.
What this interaction means in plain words
Erythromycin and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Oxybutynin belongs to Genitourinary.
Why it happens
Erythromycin inhibits CYP3A4-mediated oxybutynin metabolism.
What to do
Monitor for anticholinergic effects, particularly in older adults. Lower the oxybutynin dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Oxybutynin
Frequently asked questions
Can I take Erythromycin with Oxybutynin?
MediHelp rates the interaction as minor. Erythromycin and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin may increase oxybutynin exposure, particularly of the oral immediate-release form. This may heighten anticholinergic effects such as dry mouth, constipation, drowsiness and confusion.
How serious is the interaction between Erythromycin and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly in older adults. Lower the oxybutynin dose if adverse effects emerge.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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